Overview
Syllabus
Intro
Objectives
Antimicrobial Use Isn't Optimal
Diagnosis of Bacterial Infection is Difficult
Comparison of Clinical Biomarkers
Procalcitonin: Advantages
Community-acquired Pneumonia
Does PCT Work Outside the Research Setting?
Conclusions: Respiratory Tract Infection
The Sepsis Dilemma
PCT for Sepsis Diagnosis
PRORATA Trial
Conclusions: Sepsis/ICU
Is PCT Use Cost Effective?
Outcomes
Serum Procalcitonin Measurement and Viral Testing to Guide Antibiotic Use for Respiratory Infections in Hospitalized Adults: A Randomized Controlled Trial
Other Biomarkers of Infection
Diagnostic Test Accuracy of a 2-Transcript Host RNA Signature for Discriminating Bacterial vs Viral Infection in Febrile Children
Final Thoughts
Taught by
Mary Greeley Medical Center