Explore a comprehensive lecture from the PICC World Congress 2016 where Dr. Hector Wong delves into the use of biomarkers and enrichment strategies for sepsis clinical trials. Learn about the PERSEVERE risk model and its application in prognostic and predictive enrichment. Discover the importance of biomarkers in sepsis research, including enrichment biomarkers and bio biomarkers. Understand the use of contingency tables and performance characteristics in evaluating biomarker effectiveness. Gain insights into trial simulation, clustering algorithms, and the development of clinical tests for sepsis. Examine the Gene Expression Dynamics Inspector and methods for measuring gene expression. This informative talk covers a wide range of topics essential for researchers and clinicians involved in sepsis studies and provides valuable knowledge for improving clinical trial design and patient outcomes.
Overview
Syllabus
Introduction
Biomarkers
Enrichment
Enrichment biomarkers
Perservere model
Bio biomarkers
Contingency table
Performance characteristics
Application
Prognostic Enrichment
Trial Simulation
Predictive Enrichment
Septic shock
Clustering algorithms
Developing a clinical test
Gene Expression Dynamics Inspector
Measuring Gene Expression
Contributing Centers
Thank you
Taught by
OPENPediatrics
