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Explore the fascinating world of bio-inspired interfacial materials with super-wettability in this 49-minute award-winning talk by Lei Jiang from the Chinese Academy of Sciences. Discover how nature's ingenious designs, developed over millions of years of evolution, inspire cutting-edge materials science. Learn about original studies on super-wettability in natural systems, creative approaches to designing and fabricating smart interfacial materials, and the practical applications of these research findings. Delve into micro/nano-structured interfaces inspired by lotus leaves, rice leaves, butterfly wings, water strider legs, mosquito eyes, spider silk, and cacti. Gain insights into how bio-inspired systems not only advance scientific knowledge but also offer tremendous potential for real-world applications. Presented as the 2014 MRS Mid-Career Researcher Award talk, this lecture showcases Jiang's groundbreaking work in understanding biological systems' interfacial properties and transforming that knowledge into commercialized materials surpassing their natural counterparts.