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Explore the cutting-edge research and tools developed by the Allen Institute for Brain Science in this comprehensive lecture. Delve into the institute's history, programs, and groundbreaking work in transcriptomics, connectome mapping, and electron microscopy. Discover innovative projects like Brain TV and Visual Coding, and learn about advanced modeling techniques and optimization strategies. Gain insights into human neuron studies, the purpose behind filter models, and their applications in understanding epilepsy and neural responses. This talk, presented by Anton Arkhipov at the Simons Institute's Brain and Computation Boot Camp, offers a deep dive into large-scale datasets and modeling tools that are revolutionizing our understanding of the brain.