Acute Inflammation: Cellular Events, Rolling, and Selectins in Immunology - Part 2

Explore the intricate process of acute inflammation cellular events, focusing on rolling and selectins in this comprehensive immunology lecture. Delve into the mechanisms of neutrophil adhesion and movement along endothelial cells, a crucial step in the immune response. Learn about the role of selectins in mediating initial rolling interactions, including L-selectin on leukocytes, E-selectin on endothelium, and P-selectin on platelets and endothelium. Discover the molecular structure of selectins and their ligands, as well as the regulation of their expression by cytokines. Understand the importance of sialylated oligosaccharides and mucin-like glycoproteins as ligands for selectins. Examine the timeline of selectin expression and the role of mediators like histamine and thrombin in P-selectin redistribution. Gain insights into the induction of selectins by cytokines such as interleukin-1 and tumor necrosis factor, and their impact on endothelial cells. Explore the rapid mobilization of P-selectin from storage granules to the cell surface in response to inflammatory stimuli.