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Embark on a comprehensive journey into atom probe tomography (APT) in this informative lecture. Explore the origins and evolution of this powerful microanalysis technique that provides three-dimensional compositional mapping of materials with near-atomic resolution. Discover APT's unique ability to measure minute amounts of elements across the periodic table, from hydrogen to uranium, including at complex buried interfaces. Learn how APT complements other analytical methods such as transmission electron microscopy, secondary-ion mass spectrometry, and X-ray photoemission spectroscopy. Gain insights into recent frontier applications, including hydrogen mapping, frozen liquids analysis, and battery interface studies, made possible by cutting-edge developments in cryogenic specimen preparation and transfer. Delve into the speaker's personal contributions to the field and the advancements achieved at the Imperial Centre for Cryo Microscopy of Materials.