This course covers the latest advancement in the pathogenesis, diagnosis and treatment of the malignancies in hematology. The content of the course can reflect the frontier and latest scientific achievements in the field of hematology, including the cytogenetics, molecular biological et.al in hematopoietic and blood diseases, such as leukemia, multiple myeloma, myelodysplastic syndrome, primary immune thrombocytopenia, etc. This course is open to all graduate students and foreign students, for it is in full English。
The advancements in the diagnosis and treatment of hematologic malignancies
Shandong University via XuetangX
Overview
Syllabus
- Part1. Notch signaling pathway in hematologic diseases
- 1. Notch signaling pathway
- 2. Notch signaling and hematopoiesis
- 3. Notch signaling in T-ALL
- 4. Notch signaling in other hematologic malignancies
- 5. Notch signaling as a therapeutic target
- Part2. Leukemia
- 1. The classification of leukemia
- 2. The diagnosis of leukemia
- 3. The treatment of leukemia
- 4. Chronic Myelogenous leukemia
- Part 3 Primary immune thrombocytopenia
- 1. The pathogenesis of ITP
- 2. The diagnosis of ITP
- 3. The first-line treatment of ITP
- 4. The second-line treatment of ITP
- 5. The tentative approach for ITP
- Part 4 Hematopoietic Stem Cell Transplantation
- 1. Introduction of HSCT
- 2. Types of HSCT
- 3. Preparation for HSCT
- 4. Peripheral stem cell transplantation
- 5. The complications of HSCT
- Part 5 Genetic abnormalities in hematologic malignancies
- 1. Overview of hematological malignancies
- 2. Genetic abnormalities in AML
- 3. Genetic abnormalities in CML
- 4. Genetic abnormalities in lymphoma
- 5. Genetic abnormalities in CLL
- Part 6. Tumor immunology
- 1. Introduction of tumor immunology
- 2. Tumor antigens
- 3. Anti-tumor immune response
- 4. Mechanisms of immune evasion
- 5. Immunotherapy for tumors
- Part 7 Application of Molecular Biology in Hematology
- 1. MICM detection in hematological diseases
- 2. Molecular methods in hematological disease detection
- 3. BCR/ABL in CML
- 4. PML/RARa in APL
- 5. Gene mutations in hematological diseases
- Part 8 Hematopoiesis and Myelodysplastic syndrome(MDS)
- 1. Hematopoiesis
- 2. The history and diagnosis of MDS
- 3.Classification system for MDS
- Part 9 Platelet
- 1. Introduction of platelet and its role in thrombus formation
- 2. The regulation of platelet life span
- 3. Megakaryocyte development and platelet formation
- Examination
Taught by
Chunyan Ji, Ming Hou, Jun Peng, Jie Li, Xiaohong Liang, Daoxin Ma, Shaolei Zang, and Miao Xu
