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XuetangX

Progress in Human Embryology

Shandong University via XuetangX

Overview

The "Human Embryology" is a science that studies the normal human development as well as birth defects in the maternal uterus.


· Bridges the gap between prenatal development and obstetrics, perinatal medicine, pediatrics and clinical anatomy

· Develops knowledge concerning the beginning of life and the changes occurring during prenatal development

· Builds an understanding of the causes of variations in human structure

· Illuminates clinically oriented anatomy and explains how normal and abnormal relations develop

· Supports the research and application of stem cells for treatment of certain chronic diseases


Our better understanding of “Human Embryology” will result in new techniques for prenatal diagnosis and treatment, therapeutic procedures to circumvent problems with infertility, mechanisms to prevent birth defects and the leading cause of infant mortality.


Syllabus

  • Week 1 Introduction of Human Embryology
    • 1.1 What is human embryology?
    • 1.2 Brief history of embryology
    • 1.3 Advances of modern embryology
    • 1.4 What is teratology?
    • 1.5 Research methods of human embryology
  • Week 2 Gametogenesis and fertilization
    • 2.1 Spermatogenesis
    • 2.2 Oogenesis
    • 2.3 Fertilization
    • 2.4 Baby with three-parents
  • Week 3 First week and second week of development: Cleavage to implantation
    • 3.1 Cleavage
    • 3.2 implantation
    • 3.3 What determines whether a blastomere forms inner cell mass or trophoblast
  • Week 4 Third to eight week of development: Gastrulation and differentiation of trilaminar disc
    • Gastrulation
    • Derivatives of ectoderm
    • Derivatives of mesoderm
    • Derivatives of endoderm
    • Induction of the primitive streak
    • Teratogenesis associated with gastrulation
    • Neural induction
  • Week 5 Fetal membrane and placenta
    • Fetal membrane-Amnion
    • Fetal membrane-Yolk sac and allantois
    • Fetal membrane-Chorion
    • Fetal membrane-Umbilical cord
    • Placenta
    • HIV can be transmitted across placenta during parturition
  • Week 6 Development of the head and neck
    • Development of branchial arch and pharyngeal pouch
    • Development of face and clinical correlations
    • Development of palate and clinical correlations
    • SHH and craniofacial development
  • Week 7 Development of the digestive and respiratory system
    • 7.1 Development of primitive gut
    • 7.2 Development of foregut and clinical correlations
    • 7.3 Development of digestive glands and clinical correlations
    • 7.4 Development of the midgut and clinical correlations
    • 7.5 Development of the hindgut and clinical correlations
    • 7.6 Development of respiratory system and clinical correlations
  • Week 8 Development of urogenital system
    • Development of the primordium of the urogenital system
    • Development of kidney and ureter
    • Development of the bladder and clinical correlations
    • Development of the gonad and clinical correlations
    • Development of the genital duct and clinical correlations
    • Wnt4/Sox9 and sex determination
  • Week 9 Development of cardiovascular system
    • Formation of the heart tube
    • Partitioning of the primitive atrium
    • Partitioning of the primitive ventricle
    • Partitioning of truncus arteriosus and bulbus cordis
    • Fetal circulation
    • Circulatory Changes after birth
    • Intrauterine therapy of congenital heart disease
  • Appendix 1:Apoptosis and embryonic development
    • Introduction of apoptosis
    • Apoptosis and caspase
    • Apoptosis and embryonic development
    • Regulation of apoptosis-Bcl-2
    • Regulation of apoptosis-IAPs P53 NF-kB
    • Signaling pathway of apoptosis-Extrinsic pathway
    • Signaling pathway of apoptosis-Intrinsic pathway
    • Detection methods of apoptosis
  • Appendix 2: Autophagy and embryonic development
    • 1. What is autophagy
    • 2. Regulators of autophagy: ATGs
    • 3. Regulators of autophagy: LC3, Beclin1, DAPK
    • 4. Detection of autophagy
    • 5. Prospect of autophagy
  • Appendix 3: Mesenchymal stem cells
    • Mesenchymal stem cells
  • Appendix 4: Spermatogonial stem cells
    • Spermatogonial stem cells
  • Appendix 5: Genomic imprinting
    • Genomic imprinting
  • Appendix 6: Teaching cases for ideological and political education
    • 1. From Minamata disease to environmental health studies
    • 2. China's beloved baby doctor--Dr. Qiaozhi Lin
    • 3. Lessons for drug safety and regulation: Thalidomide tragedy
  • Popular Science Center

    Taught by

    GUO Yuji, Shangming Liu, LI Chunyang, WANG Fuwu, Yanmin Zhang, ZHANG Xiaoli, HAO Jing, and Cardio Liu

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