In Biopharmaceutical and Toxicological Analysis, the goal is to achieve an in-depth understanding of the analysis of medicines and/or their metabolites, endogenous and toxic substances in biological samples. To achieve this goal, this course has adopted a multidisciplinary approach that integrates different subjects which are complementary to each other. This approach also made it possible for students to appreciate the complexity of a subject like bioanalysis. This course sheds light on preclinical and clinical pharmacokinetics, therapeutic drug monitoring, clinical pharmacy, biopharmaceutics, drug abusing analysis, and forensic science.
Overview
Syllabus
- Chapter 1 Outline
- Chapter 2 Basic theories related to biopharmaceutical analysis
- 2.1 Drug’s in vivo process – absorption and distribution
- 2.2 Drug’s in vivo process – metabolism and excretion
- 2.3 Therapeutic drug monitoring
- 2.4 Assignment
- Chapter 3 Preparation and pretreatment of biosamples
- 3.1 Preparation and storage of commonly used biospecimens
- 3.2 Pretreatment of biospecimens (1)
- 3.3 Pretreatment of biospecimens (2)
- 3.4 Advances in pretreatment of biospecimens
- 3.5 Assignment
- Chapter 4 Development and validation of bioanalytical method
- 4.1 Design and development of bioanalytical method
- 4.2 Bioanalytical method validation (1)
- 4.3 Bioanalytical method validation (2)
- 4.4 Assignment
- Chapter 5 Chromatography and its hyphenated techniques
- 5.1 Hyphenated chromatography (1)
- 5.2 Hyphenated chromatography (2)
- 5.3 High performance capillary electrophoresis
- 5.4 Assignment
- Chapter 6 Immunoassay
- 6.1 Immunoassay (1)
- 6.2 Immunoassay (2)
- 6.3 Immunoassay (3)
- 6.4 Capillary electrophoresis-based immunoassay
- 6.5 Assignment
- Chapter 7 Cutting-edge analytical technology
- 7.1 Isotope analysis
- 7.2 Mass spectrometry imaging
- 7.3 Advances in Biopharmaceutical Analysis
- 7.4 Assignment
- Chapter 8 Bioanalysis of typical medicines
- 8.1 Bioanalysis of biotechnological drugs
- 8.2 Bioanalysis of endogenous steroid hormones
- Chapter 9 Bioanalysis of typical poisons
- 9.1 Bioanalysis of animal and plant poisons
- 9.2 Bioanalysis of of water-soluble poisons
- Chapter 10 Bioanalysis of typical illicit drugs
- 10.1 Bioanalysis of drugs of abuse
- Chapter 11 Virtual simulation experiment
- Final examination
Taught by
Chunyong Wu, Junying Zhang, Jue GAN, Chang Shu, Wenting Liao, Lifeng KANG, Mengxiang SU, Fang Yan, and Qiuling Zheng
