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XuetangX

细胞与分子生物学

Huazhong University of Science and Technology via XuetangX

Overview

Learn the fundamental principles and advanced concepts of cell and molecular biology in this comprehensive course covering seventeen key chapters. Begin with an introduction to cell biology and progress through detailed explorations of cell membranes, internal membrane systems, mitochondria, cytoskeleton, and nucleus. Master the complexities of cell connections, extracellular matrix, and signal transduction pathways. Examine cell proliferation, differentiation, aging, and various forms of cell death including apoptosis and pyroptosis. Delve into genetics with studies of genes, genomes, gene expression regulation, and epigenetic modifications. Understand DNA damage and repair mechanisms, explore cancer cells and oncogenes, and conclude with cell engineering applications. Gain practical knowledge through systematic examination of cellular structures, molecular mechanisms, and biological processes essential for understanding modern cell biology.

Syllabus

  • 第一章:细胞生物学绪论、细胞概述
    • 1.1细胞生物学的发展简史
    • 1.2细胞的特性
    • 1.3细胞生物学发展趋势
  • 第二章:细胞(质)膜
    • 2.1细胞膜—磷脂双分子层
    • 2.2膜蛋白
  • 第三章:内膜系统
    • 3.1细胞内分区及蛋白质分选
    • 3.2膜运输的分子机制
    • 3.3内吞作用_AS1
    • 3.4胞吐途径_AS1
    • 3.5内质网1
    • 3.6内质网2
    • 3.7内质网3
    • 3.8高尔基复合体1
    • 3.9高尔基复合体2
    • 3.10高尔基复合体3
    • 3.11溶酶体1_AS1-1
    • 3.12溶酶体1_AS1-2
  • 第四章:线粒体
    • 4.1绪论 线粒体动态与健康和疾病
    • 4.2线粒体超微结构和氧化磷酸化
    • 4.3内质网-线粒体膜接触位点
    • 4.4线粒体分裂的生理意义
    • 4.5线粒体分裂
    • 4.6线粒体融合
    • 4.7线粒体转运
    • 4.8自噬
    • 4.9线粒体自噬
    • 4.10线粒体生物合成
  • 第五章:细胞骨架
    • 5.1细胞骨架-1
    • 5.2细胞骨架-2
    • 5.3细胞骨架-3
  • 第六章:细胞核
    • 6.1细胞核1
    • 6.2细胞核2
  • 第七章:细胞连接和细胞外基质
    • 7.1细胞连接与细胞外基质-1
    • 7.2细胞连接与细胞外基质-2
    • 7.3细胞连接与细胞外基质-3
  • 第八章:细胞信号转导
    • 8.1细胞信号转导1
    • 8.2细胞信号转导2
  • 第九章:细胞增殖与调控
    • 9.1细胞增殖与调控1
    • 9.2细胞增殖与调控2
  • 第十章:细胞分化
    • 10.1细胞分化1
    • 10.2细胞分化2
  • 第十一章:细胞衰老与死亡
    • 11.1细胞衰老1
    • 11.2细胞衰老2
    • 11.3细胞凋亡1
    • 11.4细胞凋亡2
    • 11.5细胞凋亡3
    • 11.6细胞凋亡4
    • 11.7细胞凋亡5
    • 11.8细胞焦亡1
    • 11.9细胞焦亡2
  • 第十二章:基因与基因组
    • 12.1基因与基因组
  • 第十三章:基因表达调控
    • 13.1基因表达调控-1
    • 13.2基因表达调控-2
    • 13.3基因表达调控-3
  • 第十四章:表观遗传修饰
    • 14.1表观遗传的概念
    • 14.2表观遗传——DNA甲基化
    • 14.3表观遗传——组蛋白修饰
    • 14.4表观遗传——染色质重塑和非编码RNA
    • 14.5表观遗传——表观遗传与疾病
  • 第十五章:DNA损伤与修复
    • 15.1DNA损伤与修复
  • 第十六章:癌细胞和癌基因
    • 16.1癌细胞和癌基因
  • 第十七章:细胞工程
    • 17.1细胞工程
  • 期末考试

    Taught by

    Shi Anbing, Long Lin, Juan Chen, Weike Ji, Xuan Cao, Hongjun Yu, Yugang Wang, Lin Liu, and Yusong R. Guo

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