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XuetangX

医学分子生物学的基础与前沿进展

Shandong University via XuetangX

Overview

Medical molecular biology is a science that studies the life activities and corresponding principles of the human body and disease-related organisms in normal and disease states from the molecular level. The scientific aims of the studies are for the prevention, diagnosis and treatment of human diseases with the molecular-level technology. As a hotspot in medical-related research, the frontier advances in medical molecular biology play a key role in supporting the scientific research and innovation of graduate students in medical-related fields.

In this field, the exploration of tumorigenesis and development mechanisms, tumor prevention and treatment methods, and correlated research means has an important position. In recent years, tumor research has been changing rapidly. This course focuses on the concepts of epigenetics, cell cycle and cell death with their roles in tumorigenesis and development, tumor prevention and treatment. The related new research progress, scientific research topics and research methods are also involved in the course.

The course instructors include Zeng Jiping, Yuan Detian and Mi Ping, all from the Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shandong University.

The course references mainly come from the scientific research journals, including <Science>, <Nature>, <Cell>, <The New England Journal of Medicine>, <Cancer Cell>, <The Journal of Clinical Investigation>, <THE LANCET>, <Gastroenterology>, < Gut>, <Cancer Research>, and etc.

医学分子生物学是从分子水平研究人体和疾病相关生物在正常和疾病状态下生命活动及其规律,以及在分子水平开展人类疾病的预防、诊断和治疗研究的科学。作为一直以来的医学相关研究热点领域,医学分子生物学前沿进展对医学相关领域研究生的科研创新工作有关键的支撑作用。

在此领域中,对肿瘤发生发展机制、预防治疗方法和研究手段的探索具有重要地位。近年来,肿瘤的研究日新月异,本课程重点介绍表观遗传学、细胞周期和细胞死亡的概念、在肿瘤发生发展和预防治疗中的作用、相关新研究进展以及科学研究选题和研究方法。

课程指导教师包括曾季平、袁得天和米萍,均来自山东大学基础医学院生化与分子生物学系。

课程参考科研文献主要来自 <Science>, <Nature>, <Cell>, <The New England Journal of Medicine>, <Cancer Cell>, <The Journal of Clinical Investigation>, <THE LANCET>, <Gastroenterology>, <Gut>, <Cancer Research> 等科研期刊。


Syllabus

  • 表观遗传学(Epigenetics)
    • 表观遗传学的概念和组成 (What is epigenetics?)
    • 表观遗传学的调控机制 (Epigenetics Regulation)
    • 表观遗传学在肿瘤发生发展中的作用 (Biology and clinical importance of epigenetics-1)
    • 表观遗传学在肿瘤预防治疗中的应用 (Biology and clinical importance of epigenetics-2)
  • 肿瘤简介 (Cancer)
    • 什么是肿瘤 (What is cancer?)
    • 癌症发生的原因-1 (Possible Causes of Cancer-1)
    • 癌症发生的原因-2 (Possible Causes of Cancer-2)
    • 癌症发生的原因-3 (Possible Causes of Cancer-3)
    • 癌症的病理生理学-1 (Pathophysiology of Cancer-1)
    • 癌症的病理生理学-2 (Pathophysiology of Cancer-2)
    • 癌症的治疗方法-1 (How is Cancer Treated-1)
    • 癌症的治疗方法-2 (How is Cancer Treated-2)
  • 细胞周期 (Cell cycle)
    • 细胞周期的概念和组成 (What is cell cycle?)
    • 细胞周期的调控机制 (Regulation of cell cycle)
    • 细胞周期检查点 (Cell cycle checkpoints)
    • 细胞周期与肿瘤 (Cell cycle and cancer)
  • 细胞死亡 (Cell death)
    • 细胞死亡的概念、调控机制及与肿瘤的关系 (Cell death)
  • Final Test
    • Optional Section-模式动物研究
      • 研究背景
      • 急性BHPF暴露与心脏毒性
      • BHPF对斑马鱼幼体早期发育及睡眠/觉醒行为的影响
      • 研究总结

    Taught by

    Zeng Jiping, Yuan Detian, and Mi Ping

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