Host-Pathogen Interaction (Immunology)

Week 1: History of development of Immunology field; Branches of Immunology & An Introduction of Immune System; Overall Introduction of Immune Organ.Week 2:Immune organ: Thymus & Bone Marrow; Immune organ: Spleen, lymph node, MALT & GALT; Cells of Immune system – Hematopoiesis & Usage of early stem cells in transgenesis.Week 3:Cells of Immune system – Development of transgenic animal for immunological studies; Cells of Immune system – Application of transgenic animal for immunological studies; Cells of Immune system – Various immune cells and its role in host defense and immunopathogenesis.Week 4:Basics of cytokines and other immune mediators; Signature of inflammation & various Inflammatory mediators and other effector immune responses; Application of cytokines in therapies and research.Week 5:Introduction of innate immunity and how innate immunity influence whole immunity; Innate Immunity-Physical, Biochemical, Microbial Barriers; Innate Immunity-Pattern-recognition receptors & TLRs.Week 6:Innate Immunity-RLRs; Innate Immunity-NLRs; Innate Immunity-DNA Sensor.Week 7:Innate Immunity-Humoral components (Introduction of Complements & classical pathway); Innate Immunity- (Alternative & Lectin pathway) and complements and diseases; Adaptive Immunity (Introduction).Week 8:Antigen – A brief Introduction; B cells & Antibodies – A brief Introduction; T cells & T Cell response – A brief Introduction.Week 9:Brief introduction on innate immune responses during virus infection and how virus invade innate immunity to establish infection (part-1); Brief introduction on innate immune responses during virus infection and how virus invade innate immunity to establish infection (part-2); Brief discussion on B and T cell-mediated immune responses during virus infection and how virus invade adaptive immunity to establish infection.Week 10:Immunological responses during Influenza virus infection-(part-1); Immunological responses during Influenza virus infection-(part-2); Brief introduction of Arboviral infection.Week 11:Brief discussion on immunology of bacterial infections including immune responses to extracellular and intracellular bacteria and evasion on antagonistic mechanisms devised by bacteria to evade such responses (part-1); Brief discussion on immunology of bacterial infections including immune responses to extracellular and intracellular bacteria and evasion on antagonistic mechanisms devised by bacteria to evade such responses (part-2) & Immunology of Tuberculosis (some part); Immunology of Tuberculosis (remaining part).Week 12:Immune responses to parasite and fungal infection; Discussion about Malaria; Discussion about African Sleeping Sickness.