This course introduces concepts of drug delivery to meet medical challenges. The course is designed to be modular, with each module focusing on the various aspects of drug delivery.INTENDED AUDIENCE : Anyone in bachelors having completed two yearPREREQUISITES : None. A course in biochemistry, molecular biology, anatomy is recommendedINDUSTRY SUPPORT : All pharmaceuticals, hospitals and biotechnology industries
Drug Delivery: Principles and Engineering
Indian Institute of Science Bangalore and NPTEL via Swayam
Overview
Syllabus
Week 1: Pharmacokinetics: Bioavailability, Elimination, Therapeutic index
Week 2: Prodrugs, Controlled release
Week 3: Polymers: Synthesis, properties, characterization, crystallinity and amorphousness
Week 4: Biopolymers: Natural and Synthetic, biocompatibility, Biodegradation, commonly used biopolymers
Week 5: Polymer-Drug conjugates, PEGylation
Week 6: Diffusion controlled systems, Ficks laws, Reservoir systems, Non-erodible matrix systems, Bio-erodible Systems
Week 7: Hydrogels: Physical or chemical, pore-size calculation, in-situ crosslinking
Week 8: Nano and Micro-particles: Dendrimers, Liposomes, Micelles
Week 9: Metal and polymeric particles, effect of particle shape, charge and elasticity
Week 10: Protein Adsorption and tissue engineering, Drug delivery in tissue engineering
Week 11: Implant associated infections, Route specific delivery: Oral, Subcutaneous, Intramuscular, transdermal, inhalation, intravenous
Week 12: Vaccines, Cancer vaccines, Cell and gene delivery, Smart responsive drug delivery, Targeted drug delivery, Nanotoxicology and market translation
Taught by
Prof. Rachit Agarwal
