ABOUT THE COURSE: Biosecurity and bioterrorism are of prominent global concern, considering their profound impact on agriculture, animal production, human health, and the economy. There is a significant thrust on designing and developing more efficient sensors to detect bioterrorism agents. The present course aims to understand sensor systems' design, architecture, and efficiency to identify these agents.INTENDED AUDIENCE: Bio-Design, Bioengineering, Chemical EngineeringPREREQUISITES: High school with scienceINDUSTRY SUPPORT: Biomedical devices, Biosensor, Biowarfare and Bioterrorism solutions
Overview
Syllabus
Week 1 : Challenges of biosecurity
Week 2 : Need for economic sensors to meet the emerging threats of biosecurity
Week 3 : Design of electrochemical sensors
Week 4 : Electrode design and printing of electrodes
Week 5 : Electrode design and printing of electrodes
Week 6 : Electrodes, potentiometry
Week 7 : Electrodes, potentiometry
Week 9 : Electro-analytical methods
Week 10 : Electro-analytical methods
Week 11 : Designing human-on-a-chip platforms for toxin detection, neurocomputing, robotics, and rehabilitation
Week 12 : Designing of a biosecurity facility
- Agriculture Security
- Livestock production
- Human health
- Pandemics
- Bioterrorism
Week 2 : Need for economic sensors to meet the emerging threats of biosecurity
- Case study for Filoviruses (Ebola, Marburg) sensor
- Case study for Bacillus anthracis (Anthrax) sensor
- Case study of botulism toxin
- Case study of insulin
Week 3 : Design of electrochemical sensors
- Galvanic cells
- Nernst equation
- Equilibrium constant
- Cells as a chemical probe
- Concepts of E0 and E0’
Week 4 : Electrode design and printing of electrodes
- Selection of electrode materials for rapid sensing
- Bio-inspired electrode materials
Week 5 : Electrode design and printing of electrodes
- Processing of electrode materials
- Printing of electrodes
- Design challenges of electrode integration in protective technical textiles and defence gears
Week 6 : Electrodes, potentiometry
- Reference electrode
- Indicator electrode
Week 7 : Electrodes, potentiometry
- Junction potential
- Ion-selective electrode
- Solid-state chemical sensors (Fields effect transistors)
- Redox titration curves
- Determination of endpoints
- The oxidation state of the analyte
Week 9 : Electro-analytical methods
- Basic electrolysis
- Electro-gravimetric analysis
Week 10 : Electro-analytical methods
- Coulometry
- Amperometry
- Voltammetry
Week 11 : Designing human-on-a-chip platforms for toxin detection, neurocomputing, robotics, and rehabilitation
- Concepts of whole cell biosensors
- Neuro-technology
- Action potential shape analysis in toxin detection & role of voltage gating molecules
- Micro-electrode arrays
- Field effect transistors
Week 12 : Designing of a biosecurity facility
- Infrastructure
- Instrumentation
- Sample handling, quarantine protocols, biosafety levels, personnel safety and security
- In-house fabrication, printing, and micro-machining facility
- Data analysis & storage
Taught by
Prof. Mainak Das
