This course will focus on the use of efficient technologies used in the protein modeling and its analysis on the basis of the available amino acid or gene sequences.During this course, candidates learned the introduction to the basic biology required for computational structural designing along with Modeling software. The course includes hands-on exercises on sequence searching (genes & Proteins) and the protein structure design and its analysis approach.
Computational Protein Modeling and Analysis
IGNOU and Chhattisgarh Swami Vivekanand Technical University via Swayam
Overview
Syllabus
Week
Topics
Video Title
Week-1
Cell Biology
Basic Biology-I
Microbiology
Basic Biology-II
Virology
Basic Biology-III
Week-2
Molecular Biology
Basic Biology-IV
Chromosomes and Genes
Basic Biology-V
Amino acids and Protein Synthesis
Basic Biology-VI
Week-3
History and development of computers, Computer Coding, Number system
Basics of Computer-I
Languages and flow charts and Operating Systems
Basics of Computer-II
Modern Computers, Supercomputers, Internet and related programs, Introduction to Biostatistics
Basics of Computer-III
Week-4
Basics about Protein
Introduction to Protein
Detail about primary structure of Protein
Primary structures of Protein
Secondary Structure with method of identification
Secondary Structure with method of identification
Detail about Tertiary Structure
Tertiary Structure
Detail about Quaternary Structure
Quaternary Structure
Week-5
Introduction to Bioinformatics, Origin and History of Bioinformatics,
Introduction to Bioinformatics
Introduction to alignment and Types of Alignments Global and. Local alignment
Sequence Alignment
Pair wise Alignment, Multiple Sequence Alignment
Types of alignment-I
Clustal W Tool
Types of alignment-II
Week-6
Basic Local Alignment Search Tool with demo
BLAST-I
Alignment Search Tool with demo
BLAST-II
Structural determination and Types of Molecular Modeling
Structure Determination and Molecular Modeling
Week-7
Different Types of Search Tools
Database Search
Details About NCBI
Database Search NCBI-I
NCBI searching
Database Search NCBI-II
Week-8
Introduction and detail about RCSB
Database Search RCSB-I
Searching in RCSB
Database Search RCSB-II
Week-9
Details about Modeler and protein modeling through Modeler
Modeling Software-I
Details about different Modeler and protein modeling through other Modeler
Modeling Software-II
Week-10
Introduction and features of SWISS-Model
Modeling Server SWISS-Model
Introduction and features of The Pipeline
Modeling Server The Pipeline
Introduction and features of The Workspace
Modeling Server The Workspace
Week-11
Introduction and features of Modeling Server The Repository
Modeling Server The Repository
Introduction and features of Modeling Server 3D-JIGSAW
Modeling Server 3D-JIGSAW
Introduction and features of Modeling Server Geno3D
Modeling Server Geno3D
Week-12
Details about Rasmol with Demo
Protein Structure Visualization Tool-I
Details about Swiss-PDB Viewer with Demo
Protein Structure Visualization Tool-II
About Procheck tool
Structure Validation-1
About WHAT IF server
Structure Validation-2
About PROSA
Structure Validation-3
Computer, Biology and Modeller
Conclusion and Revision
Taught by
Prof. M. K. Verma & Dr. Ashish Patel
