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This free course is concerned with some of the statistical methods used in epidemiology and more widely in medical statistics. Section 1 introduces cohort studies in which individuals are classified according to their exposure and followed forward in time to evaluate disease outcomes. Section 2 looks at models for cohort studies. Section 3 introduces case-control studies in which individuals are selected according to their disease status and past exposures are then ascertained. Section 4 covers testing for no association in cohort studies and case-control studies.