Metal Mediated Synthesis - I

Overview

The course covers an advance level of organometallic chemistry. Recent development of cross coupling reactions and their applications in organic synthesis, starting from small molecule to naturally and pharmaceutically important compounds, has been described in the prescribed course. In this course, a brief overview about the carbine chemistry and oxidative cyclization is also portrayed.INTENDED AUDIENCE: Students, PhD scholars, teachers, industry.PREREQUISITES: Advance Organic and Inorganic Chemistry.INDUSTRY SUPPORT: All Pharmaceutical Industries.

Syllabus

Week 1 :
Lecture 1: Assymetric HydrogenationLecture 2: Transition metal carbenes,Fischer and Schrock carbenesLecture 3: Olefin metathesisLecture 4: Alkyne metathesisLecture 5: Cyclopropanation reaction
Week 2 :
Lecture 6: Catalytic cyclopropanation reaction,Introduction to cross coupling reactionLecture 7: Kumada Coupling reactionLecture 8: Suzuki coupling reactionLecture 9: Stille coupling reactionLecture 10:Assymetric Suzuki coupling reaction
Week 3 :
Lecture 11: Sonogashira coupling reactionLecture 12: Heck coupling reactionLecture 13: Assymetric Heck reaction,Introduction to Buchwald-Hartwig coupling reactionLecture 14: Buchwald-Hartwig coupling reactionLecture 15: Role of Ligands its influence in Buchwald-Hartwig coupling reaction
Week 4 :

Lecture 16: Oxidative cyclization processLecture 17: Application of oxidative cyclization in natural product synthesisLecture 18: Synthesis of reactive metallacycle intermediate via-Beta-abstraction and their applicationsLecture 19: Kulinkovich Reaction and its mechanismLecture 20: Pauson–Khand reaction