This course explores the world-wide crisis and challenge of substance abuse, including its historical effects on various societies and cultures. In addition to examining this from a social perspective, students receive an overview of the epidemiology and toxicology of substance abuse and its relevance to personal and public health. Students are introduced to the concept of substance abuse and dependence, the definition of licit and illicit drugs, and the pharmacologic, neurologic, and physiologic effects of selected substances on the human brain. Political, social, and economic factors involved in the supply and demand for drugs are discussed. Epidemiologic data on the prevalence, incidence, and trends of smoking, alcohol, and prescription and other drug dependencies globally are covered, as well as risk factors associated with the use and abuse of these substances. Current options for recovery are reviewed.