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In this course we will explore the intersection of statistics and functional magnetic resonance imaging, or fMRI, which is a non-invasive technique for studying brain activity. We will discuss the analysis of fMRI data, from its acquisition to its use in locating brain activity, making inference about brain connectivity and predictions about psychological or disease states. A standard fMRI study gives rise to massive amounts of noisy data with a complicated spatio-temporal correlation structure. Statistics plays a crucial role in understanding the nature of the data and obtaining relevant results that can be used and interpreted by neuroscientists.