Telomere-to-Telomere Chromosome Assemblies: New Insights Into Genome Biology and Structure

Telomere-to-Telomere Chromosome Assemblies: New Insights Into Genome Biology and Structure

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Intro

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1 of 19

Intro

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Telomere-to-Telomere Chromosome Assemblies: New Insights Into Genome Biology and Structure

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  1. 1 Intro
  2. 2 Human Reference Genome: Foundational for Genomic Research
  3. 3 Need to generate and analyze complete human genomes
  4. 4 Effectively Haploid Genome
  5. 5 Repeat Assembly
  6. 6 Genome assembly, 2001
  7. 7 Custom assembly pipeline for T2T Reconstruction
  8. 8 Assembly Evaluation: Accurate Repeat Mapping
  9. 9 Accurate Alignments and Variant Calling
  10. 10 The complete sequence of a human genome
  11. 11 Acrocentric Short Arms
  12. 12 High Resolution Maps of Human Peri/Centromeric Regions
  13. 13 Discovery of candidate genes and coding regions
  14. 14 The majority of sequences centromeric regions are defined by collections of satellite arrays
  15. 15 Repeat Discovery and Classification
  16. 16 Comprehensive maps of segmental duplications
  17. 17 T2T Methylation Profiling with UL Nanopore Data
  18. 18 Complete (T2T) Assemblies will Revolutionize Genetics and Genomics
  19. 19 Celebration of collaborative, open science TT

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