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Telomere-to-Telomere Chromosome Assemblies: New Insights Into Genome Biology and Structure
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- 1 Intro
- 2 Human Reference Genome: Foundational for Genomic Research
- 3 Need to generate and analyze complete human genomes
- 4 Effectively Haploid Genome
- 5 Repeat Assembly
- 6 Genome assembly, 2001
- 7 Custom assembly pipeline for T2T Reconstruction
- 8 Assembly Evaluation: Accurate Repeat Mapping
- 9 Accurate Alignments and Variant Calling
- 10 The complete sequence of a human genome
- 11 Acrocentric Short Arms
- 12 High Resolution Maps of Human Peri/Centromeric Regions
- 13 Discovery of candidate genes and coding regions
- 14 The majority of sequences centromeric regions are defined by collections of satellite arrays
- 15 Repeat Discovery and Classification
- 16 Comprehensive maps of segmental duplications
- 17 T2T Methylation Profiling with UL Nanopore Data
- 18 Complete (T2T) Assemblies will Revolutionize Genetics and Genomics
- 19 Celebration of collaborative, open science TT
