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Intro
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Identifying Decisions in Biological Systems: Toward Understanding and Control
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- 1 Intro
- 2 My group's research focus: modeling the dynamics of systems of interacting elements
- 3 Connect within-cell networks to cell behavior through discrete dynamic modeling
- 4 The dynamic model is built from experimental data and is tested on experimental data
- 5 A parsimonious and informative modeling approach: discrete dynamics (logical modeling)
- 6 Model - experiment cycles involving our group
- 7 Integration of the interaction network and of the regulatory functions allows causal insight
- 8 Example: gradual commitment in the cell cycle Phase Switch
- 9 The concept of stable motif is preserved in continuous dynamical systems
- 10 Example: Boolean model of epithelial to mesenchymal transition (EMT)
- 11 Example: preventing C. albicans yeast-to-hyphal transition
