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STD NMR for drug target interactions
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Classroom Contents
Principles and Applications of NMR Spectroscopy
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- 1 Introduction to NMR spectroscopy
- 2 The alignment of nuclear spins in presence of magnetic field
- 3 Introduction to rotating frame
- 4 Free induction decay and Fourier transformation of FID
- 5 NMR Hardware
- 6 The concept of chemical shift
- 7 Factors that affect chemical shifts
- 8 Chemical shift referencing
- 9 J- coupling
- 10 Recap of basics
- 11 Introduction to general one dimensional NMR experiment
- 12 Practical aspects of recording a 1D NMR experiment I
- 13 Practical aspects of recording a 1D NMR experiment II
- 14 Lec14 Practical aspects of recording a 1D NMR experiment III
- 15 NMR Data processing
- 16 Basic aspects of 1D proton NMR analysis
- 17 Analysis of an example 1D proton spectrum
- 18 Analysis of 1D 1H NMR spectra of molecules I
- 19 Analysis of 1D 1H NMR spectra of molecules II
- 20 1D 13C NMR
- 21 Why do we need 2D NMR
- 22 A qualitative explanation of how 2D NMR experiment works
- 23 Principles of 2D COSY and Total correlation spectroscopy (2D TOCSY)
- 24 2D NOE-spectroscopy
- 25 2D NOESY and 2D ROESY
- 26 What is heteronuclear correlation NMR spectroscopy
- 27 Sensitivity enhancement of heternuclei via polarization transfer
- 28 Heteronucler multiple(2D HMQC) and single quantum NMR spectroscopy (2D HSQC)
- 29 Practical aspects of recording and processing 2D HMQC or HSQC
- 30 HMBC and its utility
- 31 2D HSQC TOCSY and its analysis with examples
- 32 Structure determination of molecules by NMR
- 33 Structure determination of peptides I
- 34 Structure determination of peptides II
- 35 Structure determination of peptides III
- 36 Chemical exchange
- 37 Hydrogen or deuterium exchange
- 38 Diffusion ordered spectroscopy DOSY I
- 39 DOSY II
- 40 STD NMR for drug target interactions
