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Precision Dosing of Antibody Therapeutics: PET Imaging for Quantifying Activity in Tumors
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- 1 Intro
- 2 Success of Anti-cancer Therapies
- 3 Drug-centric Approach Antibodies as imaging agents
- 4 Target-centric Approach Quantify target pharmacodynamics at the disease site
- 5 A Pharmacodynamics Approach to Quantify Antibody Activity at the Disease Site Measuring the target instead of the drug
- 6 Programmed Death Ligand 1 (PD-L1) A target for imaging immune checkpoint blockade
- 7 PD-L1 Imaging Agents with Improved Image Contrast [18F]DK222
- 8 Dose Finding and Optimization of Antibody Therapeutics
- 9 Quantification of Accessible PD-L1 Levels at the Tumor for dose finding and dose optimization
