Precision Dosing of Antibody Therapeutics: PET Imaging for Quantifying Activity in Tumors

Precision Dosing of Antibody Therapeutics: PET Imaging for Quantifying Activity in Tumors

Johns Hopkins Medicine via YouTube Direct link

Intro

1 of 9

1 of 9

Intro

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Precision Dosing of Antibody Therapeutics: PET Imaging for Quantifying Activity in Tumors

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  1. 1 Intro
  2. 2 Success of Anti-cancer Therapies
  3. 3 Drug-centric Approach Antibodies as imaging agents
  4. 4 Target-centric Approach Quantify target pharmacodynamics at the disease site
  5. 5 A Pharmacodynamics Approach to Quantify Antibody Activity at the Disease Site Measuring the target instead of the drug
  6. 6 Programmed Death Ligand 1 (PD-L1) A target for imaging immune checkpoint blockade
  7. 7 PD-L1 Imaging Agents with Improved Image Contrast [18F]DK222
  8. 8 Dose Finding and Optimization of Antibody Therapeutics
  9. 9 Quantification of Accessible PD-L1 Levels at the Tumor for dose finding and dose optimization

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