Phase Separation in Living Cells by Frank Jülicher

Phase Separation in Living Cells by Frank Jülicher

International Centre for Theoretical Sciences via YouTube Direct link

Chemically active droplets

27 of 43

27 of 43

Chemically active droplets

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Phase Separation in Living Cells by Frank Jülicher

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  1. 1 Acknowledgements
  2. 2 Cellular compartments
  3. 3 Outline
  4. 4 Membraneless compartments
  5. 5 granules
  6. 6 granule assembly gradient
  7. 7 granules are liquid drops
  8. 8 Liquid-liquid phase separation
  9. 9 Phase transition in a cell
  10. 10 Phase diagram
  11. 11 Active processes: fluctuations
  12. 12 Thermodynamics of phase coexistence
  13. 13 Droplet coexistence
  14. 14 In vitro droplet ripening
  15. 15 Ostwald ripening
  16. 16 Droplet fusion: hydrodynamics
  17. 17 Cell polarity
  18. 18 Protein gradient drives granule segregation
  19. 19 RNA binding competition
  20. 20 Stochastic droplet dynamics
  21. 21 Concentration buffering
  22. 22 Stochastic protein production
  23. 23 Noise buffering by phase separation
  24. 24 Noise buffering in Experiments
  25. 25 Condensates as chemical reaction centers
  26. 26 Droplet turnover: detailed balance
  27. 27 Chemically active droplets
  28. 28 Steady state of active droplets
  29. 29 Dynamics of active droplets
  30. 30 RNA-protein assemblies organize chemistry in space
  31. 31 Droplets in early life?
  32. 32 Active droplets as simple models for photocells
  33. 33 Division of active droplets
  34. 34 Growth-division cycles
  35. 35 Hardening of protein condensates
  36. 36 Pulling on condensates: material properties
  37. 37 Surface tension from active micro-rheology
  38. 38 Time periodic forcing
  39. 39 Aging of protein condensates
  40. 40 Increasing relaxation time: glassy dynamics
  41. 41 Gel formation versus aging glass
  42. 42 Glassy dynamics: disorder of
  43. 43 Conclusions

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