Organic Chemistry in Biology and Drug Development

Organic Chemistry in Biology and Drug Development

IIT Kharagpur July 2018 via YouTube Direct link

Lecture 14 : Enzyme catalysed reactions and introduction to catalytic activity of proteases

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15 of 64

Lecture 14 : Enzyme catalysed reactions and introduction to catalytic activity of proteases

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Organic Chemistry in Biology and Drug Development

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  1. 1 Organic Chemistry in Biology and Drug Development
  2. 2 Lecture 1 : A brief introduction to Molecules of Life
  3. 3 Lecture 2 : Biological Macro molecules and Small molecules: Importance and functions
  4. 4 Lecture 3 : Amino Acids: The building block of proteins
  5. 5 Lecture 4 : Amino acids: separation and detection, Electrophoresis and Ninhydrin reaction
  6. 6 Lecture 5 : Method of determination of Amino acid sequence: primary structure of polypeptide/protein
  7. 7 Lecture 6 : Selective peptide bond cleavage: Enzymatic and Non-enzymatic methods
  8. 8 Lecture 7 : Peptide synthesis: Protecting groups for amine and carboxyl functionality
  9. 9 Lecture 8 : Peptide synthesis (continued): Protection, coupling and deprotection methods
  10. 10 Lecture 9 : Recent development of coupling agents;
  11. 11 Lecture 10 : Hierarchial structure of proteins: Secondary, tertiary and quaternary structure
  12. 12 Lecture 11 : Ramachandran plot and protein purification techniques
  13. 13 Lecture 12 : Protein Purification Techniques (Contd.)
  14. 14 Lecture 13 : Introduction to Enzymes and its kinetics
  15. 15 Lecture 14 : Enzyme catalysed reactions and introduction to catalytic activity of proteases
  16. 16 Lecture 15 : Enzyme Kinetics (Contd.)
  17. 17 Lecture 16 : Concept of Enzyme Inhibition
  18. 18 Lecture 17 : Concept of Enzyme Inhibition (Contd.)
  19. 19 Lecture 18 : Problems on Enzyme Kinetics and Enzyme Inhibition
  20. 20 Lecture 19 : Synthetic Biology
  21. 21 Lecture 20 : Synthetic Biology (Contd.)
  22. 22 Lecture 21 : Synthetic Biology (Contd.)
  23. 23 Lecture 22 : Nucleic Acid
  24. 24 Lecture 23 : Nucleic Acid (Contd.)
  25. 25 Lecture 24 : DNA sequencing method
  26. 26 Lecture 25 : DNA sequencing method (Contd.)
  27. 27 Lecture 26 : DNA sequencing method (Contd.)
  28. 28 Lecture 27 : Synthesis of oligonucleotide
  29. 29 Lecture 28 : Central dogma: DNA replication, transcription and translation
  30. 30 Lecture 29 : Central dogma: DNA replication, transcription and translation (Contd.)
  31. 31 Lecture 30 : Central dogma: DNA replication, transcription and translation (Contd.)
  32. 32 Lecture 31 : Central dogma: DNA replication, transcription and translation ((Contd.)
  33. 33 Lecture 32 : Central dogma: DNA replication, transcription and translation (Contd.)
  34. 34 Lecture 33 : Molecular Biology
  35. 35 Lecture 34 : Molecular Biology (Contd.)
  36. 36 Lecture 35 : Chemistry of cofactors/coenzymes
  37. 37 Lecture 36 : Chemistry of cofactors/coenzymes (Contd.)
  38. 38 Lecture 37 : Chemistry of cofactors/coenzymes (Contd.)
  39. 39 Lecture 38 : Chemistry of cofactors/coenzymes (Contd.)
  40. 40 Lecture 39 : Chemistry of cofactors/coenzymes (Contd.)
  41. 41 Lecture 40 : Chemistry of cofactors/coenzymes (Contd.)
  42. 42 Lecture-41: " Introduction to Drug Discovery Process"
  43. 43 Lecture-42: " Fundamental Principles of Drug Development Process"
  44. 44 Lecture-43: " Combinatorial chemistry"
  45. 45 Lecture-44: "Neurotransmitters"
  46. 46 Lecture-45: " Catechol amine based and GABA neurotransmitters"
  47. 47 Lecture-46: " Hypertension: humoral mechanism and renin/angiotensin system"
  48. 48 Lecture-47: " Inhibitor design of angiotensin converting enzyme"
  49. 49 Lecture 48: Antimicrobial drugs
  50. 50 Lecture 49: Chemistry of penicillins
  51. 51 Lecture 50: Resistance to beta-lactam antibiotics
  52. 52 Lecture 51: Mechanistic studies of beta-lactamase
  53. 53 Lecture 52: Non beta-lactam antibiotics
  54. 54 Lecture 53: Mechanistic enzymology of Isopenicillin N synthase
  55. 55 Lecture-54 : Polyketide Biosynthesis
  56. 56 Lecture 55 : Biosynthesis of macrolide polyketides and introduction to virus
  57. 57 Lecture 56 : Anti-viral drugs
  58. 58 Lecture-57 : Cancer and Chemotherapy
  59. 59 Lecture-58 : Anti-cancer drugs (contd)
  60. 60 Lecture 59 : Aromatase inhibition and Anti-ulcer drugs
  61. 61 Lecture-60 : Cholesterol lowering agents
  62. 62 Lecture 61 : Cholesterol Biosynthesis
  63. 63 Lecture-62 : Pharmakinetics and pharmadynamics
  64. 64 Lecture-63 : QSAR principles

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