Variational Inference for Large-Scale Genomic Data - CGSI 2022

Variational Inference for Large-Scale Genomic Data - CGSI 2022

Computational Genomics Summer Institute CGSI via YouTube Direct link

Intro

1 of 15

1 of 15

Intro

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Variational Inference for Large-Scale Genomic Data - CGSI 2022

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  1. 1 Intro
  2. 2 Genome-wide association studies
  3. 3 GWAS does not provide causal mechanisms
  4. 4 Global biobanks reflect massive scale of available genome/phenome
  5. 5 Large-scale genomic analyses require scalable inference
  6. 6 Have you heard the good word of Thomas Bayes?
  7. 7 Variational approaches for approximate Bayesian inference I
  8. 8 Integrate molecular/functional information to understand disease mechanisms
  9. 9 Large-scale application to blood GWAS
  10. 10 TWAS identifies 6,236 and 116 genes for EA and AA across 15 traits
  11. 11 Gene sets by MA-FOCUS are more enriched for hematopoietic categories
  12. 12 Integrate phenome information to understand disease mechanisms
  13. 13 FactorGO: Factor analysis for genetic associations
  14. 14 FactorGO leverages information in under-powered studies
  15. 15 FactorGO finds greater enrichment at functionally relevant genomic annotations

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