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How Cells Divide Labor Using Communication and Spatial Cues - 2023
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- 1 Intro
- 2 Tissue division of labor can be regulated by superimposed signals and cell-cell interactions
- 3 Intestinal enterocytes, which are mainly affected by an oxygen gradient along the intestinal villus, show a continuum of specialization
- 4 What would be the optimal task allocation for cells that use cell-cell interactions to regulate their performance?
- 5 We model the collective performance of the cells considering that cells' performance is affected by the performance of their neighbor cells
- 6 Cell-cell interactions can lead to diverse patterns in gene expression and tissue space
- 7 We consider the fibroblasts population in order to test our theoretical predictions
- 8 There is potential cross-talk between every pair of colon fibroblasts archetypes
- 9 Fibroblasts potentially use lateral inhibition to divide labor
- 10 In the absence of spatial information, archetype crosstalk networks can be used to dissect communication-driven tissue organization
