Lysosome Function in Brain Health and Disease - From Tool Development to Novel Biology

Lysosome Function in Brain Health and Disease - From Tool Development to Novel Biology

Wu Tsai Neurosciences Institute, Stanford via YouTube Direct link

How does CLN3 deficiency lead to neuronal cell death in Batten disease?

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How does CLN3 deficiency lead to neuronal cell death in Batten disease?

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Lysosome Function in Brain Health and Disease - From Tool Development to Novel Biology

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  1. 1 Intro
  2. 2 The lysosome is an example of the optimized subcellular biochemistry: it degrades macromolecules to recycle their nutrient content
  3. 3 Understanding these functions might be key for understanding a wide range of human disease
  4. 4 Subcellular metabolism as a new approach to study organelle dysfunction in human disease
  5. 5 Untargeted metabolomics reveals the accumulation of Glycerophosphodiesters (GPDs) in CLN3 deficient lysosomes
  6. 6 How does CLN3 deficiency lead to neuronal cell death in Batten disease?
  7. 7 Decreased contribution of GPC-derived choline to lipid biosynthesis in CLN3 KO-neurons
  8. 8 Lysosomal choline metabolism is essential for brain homeostasis
  9. 9 Choline: an essential metabolite in physiology
  10. 10 What are the principal sources of choline?
  11. 11 Endolysosomal CRISPR-Cas9 screen to identify lysosomal proteins important for surviving choline deprivation
  12. 12 Phosphocholine and choline are not accumulating in SPNS1- deficient lysosomes
  13. 13 SPNS1-deficient lysosomes accumulate lysophosphocholine (LPC) and lysophosphoethanolamine (LPE)
  14. 14 LPCs generated in lysosomes are trapped in SPNS1-deficient lysosomes
  15. 15 SPNS1 is a lysosomal lysophospholipid transporter
  16. 16 A novel lysosomal phospholipid salvage pathway

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