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Disease Mechanism and Genetic Analysis: From GWAS to Biological Insights - Lecture 18
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- 1 Lecture Overview
- 2 Review: Genetics, Variation, GWAS, Polygenic scores PGS
- 3 From GWAS to biological insights
- 4 Bayesian Fine-Mapping
- 5 Sub-threshold Region Prioritization
- 6 GWAS locus dissection: enriched tissues, driver SNPs, target genes
- 7 Partitioning complex traits into tissue-specific components
- 8 From Individual GWAS Region to Mechanism and Circuitry
- 9 Introduction to FTO locus, strongest Genetic Association with Obesity
- 10 Step 1 - Establish relevant tissue/cell type
- 11 Step 2 - Establish downstream target genes
- 12 Step 3 - Establishing causal nucleotide variant
- 13 Step 4 - Establish upstream regulator causality
- 14 Step 5 - Establish cellular phenotypic consequences
- 15 Step 6 - Establish organismal phenotypic consequences
- 16 Quantitative Trait Loci: eQTL/meQTLanalysis
- 17 Mediation Analysis + Mendelian Randomization
- 18 Heritability and Systems Genetics
- 19 Partitioning heritability by functional annotations
- 20 Omnigenic vs. polygenic vs. monogenic inheritance
- 21 Summary
