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Challenge of Mechanism
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Classroom Contents
Disease GWAS, PRS, and Genetic Mechanisms in Modern Medicine - Lecture 17
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- 1 Genetics: From Ancient Times to Today
- 2 Disease-associated Variants
- 3 Challenge of Mechanism
- 4 Variation and Disease
- 5 Defining Variants
- 6 Common Variants and Haplotype Blocks
- 7 GWAS Genome-wide Association Studies: Genotype-Phenotype
- 8 Common/weak-effect vs. Rare/Strong-effect variants
- 9 Family studies Linkage Analysis vs. Unrelated Individuals GWAS
- 10 Population Differences, Ancestry Painting, PCA, Multi-Ethnic Fine-Mapping
- 11 Polygenic Scores PGS and Polygenic Risk Scores PRS
- 12 Mechanistic Insights from Genome-Wide Functional Enrichments
- 13 Summary
