Treatment Development for Neuropsychiatric Disturbances in Dementia: Past, Present, Future - Grand Rounds

Treatment Development for Neuropsychiatric Disturbances in Dementia: Past, Present, Future - Grand Rounds

Johns Hopkins Medicine via YouTube Direct link

Intro

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1 of 17

Intro

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Treatment Development for Neuropsychiatric Disturbances in Dementia: Past, Present, Future - Grand Rounds

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  1. 1 Intro
  2. 2 Learning objectives
  3. 3 Facing reality: balancing "cure" with "care"
  4. 4 Auguste D: hospitalized for delusions and change in personality, not cognitive impairment
  5. 5 NPS are UNIVERSAL (97%) & fluctuate Cache County Dementia Progression Study
  6. 6 Eco-psychosocial interventions behavioral, environmental, caregiver focused
  7. 7 Medication treatment development for NPS The past: BEFORE 2011
  8. 8 Medication Rxs disappointing when using existing DSM/ICD phenotypes
  9. 9 Antipsychotics: small benefit Antipsychotics carry "BLACK BOX" warning
  10. 10 Challenges of DSM-IV phenotypes
  11. 11 Overlap of symptoms Cache County Dementia Progression Study
  12. 12 Hypotheses based on etiology
  13. 13 The future: 2023 and beyond Novel medications for agitation
  14. 14 Serotonin system loss in AD early but not universal, interacts with ATN
  15. 15 Response limited to a subgroup HETEROGENEITY
  16. 16 Response depends on agitation phenotype Affective vs. Dysexecutive
  17. 17 Breaking down the heterogeneity of NPS The future: 2023 and beyond

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