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A Tutorial on Computational Methods for Modeling and Analyzing Epigenomic Data
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- 1 Intro
- 2 The epigenome provides cell type specific markers
- 3 Supervised Integration of Multiple Chromatin Marks
- 4 Approach: Multivariate Hidden Markov Model (ChromHMM)
- 5 ENCODE: Study nine marks in nine human cell lines
- 6 Chromatin state annotations exhibit cell type specific enrichments of GWAS hits
- 7 Regulatory Activity in DNA Accessible Sites Depends on Chromatin State
- 8 Three Options for Applying ChromHMM to Multiple Cell Types
- 9 Stacked Modeling Provides Complementary Advantanges to Concatenated Model
- 10 ChromGene applied to Roadmap Epigenomics data
- 11 ChromGene annotations relationship with gene expression
