Introduction to the Coalescent Theory - Lecture 3

Introduction to the Coalescent Theory - Lecture 3

International Centre for Theoretical Sciences via YouTube Direct link

Summary

16 of 48

16 of 48

Summary

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Introduction to the Coalescent Theory - Lecture 3

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  1. 1 Third Bangalore School on Population Genetics and Evolution
  2. 2 Introduction to the coalescent theory
  3. 3 Selection and the coalescent
  4. 4 The ancestral selection graph
  5. 5 The Moran model
  6. 6 The biased voter model
  7. 7 The dual process
  8. 8 The ancestral selection graph
  9. 9 The conditional structured coalescent
  10. 10 Balancing selection
  11. 11 A peak of polymorphism is expected. .
  12. 12 Positive directional selection
  13. 13 Example: maize and teosinte
  14. 14 Purifying selection
  15. 15 Why purifying selection may reduce Ne
  16. 16 Summary
  17. 17 What is it good for?
  18. 18 Detecting selection
  19. 19 Allele frequency distribution
  20. 20 Polymorphism & divergence
  21. 21 Haplotype sharing
  22. 22 Standard approach 80's-90's
  23. 23 Plants vs flies
  24. 24 The CCR5-32 AIDS-
  25. 25 This approach is now dead
  26. 26 Sample size over time
  27. 27 You too, Drosophila!
  28. 28 "It is difficult to get a man to understand something when his salary depends upon his not understanding it.
  29. 29 Two possible ways out
  30. 30 Forget about p-values
  31. 31 Calibrating background models
  32. 32 But no model fits Arabidopsis...
  33. 33 Testing for local adaptation
  34. 34 Field experiments Schmitt et al
  35. 35 Alleles associated with fitness advantage are local
  36. 36 Schmitt et al
  37. 37 "The method has been shown to be robust to demography..."
  38. 38 "The method has been sh to be robust co
  39. 39 etched has been
  40. 40 "No evidence for population structure was found..."
  41. 41 evidence for ture was found...
  42. 42 Moral of the story
  43. 43 I'm not depressed
  44. 44 Gene trees & species trees
  45. 45 A. haller
  46. 46 The pairwise sequentially Markovian coalescent model
  47. 47 Problem: the ARG is not Markovian...
  48. 48 "Effective population size" over time ...

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