Introduction to Coalescent Theory - Lecture 1

Introduction to Coalescent Theory - Lecture 1

International Centre for Theoretical Sciences via YouTube Direct link

Summary

15 of 40

15 of 40

Summary

Class Central Classrooms beta

YouTube videos curated by Class Central.

Classroom Contents

Introduction to Coalescent Theory - Lecture 1

Automatically move to the next video in the Classroom when playback concludes

  1. 1 Third Bangalore School on Population Genetics and Evolution
  2. 2 Introduction to the coalescent theory
  3. 3 The Gregor Mendel Institute
  4. 4 The Coming of Data
  5. 5 "We cranked the handle and nothing came genome chromosome 21
  6. 6 Example: Polymorphism in the human genome chromosome 21
  7. 7 Making sense of sequence data
  8. 8 The neutral model
  9. 9 History
  10. 10 Importance
  11. 11 Three insights
  12. 12 Some English
  13. 13 The neutral Wright-Fisher model
  14. 14 The Wright-Fisher model
  15. 15 Summary
  16. 16 The coalescent and classical population genetics
  17. 17 Implications for how we should view polymorphism data
  18. 18 Example: mitochondrial Eve
  19. 19 The coalescent
  20. 20 Topology & branch lengths
  21. 21 Distribution of the branch lengths
  22. 22 Scale time so that one unit of scaled time corresponds to N generations.
  23. 23 Let Tk be the
  24. 24 Summary
  25. 25 What do coalescence trees look like?
  26. 26 Deep branches often dominate
  27. 27 Example: How big a sample is needed to include the MRCA of everyone?
  28. 28 What do larger coalescence trees look like?
  29. 29 Distribution of the topology
  30. 30 Example: ancient Neanderthal mtDNA
  31. 31 The mutation rate
  32. 32 The probability of "identity by descent"
  33. 33 Superimposing mutations
  34. 34 The expected number of mutations is:
  35. 35 Note that
  36. 36 Mutation models
  37. 37 Estimating 0 under the infinite-sites model
  38. 38 segregating polymorphic sites, S.:
  39. 39 Both are unbiased, however,
  40. 40 How do we detect deviations from the standard model e.g., growth?

Never Stop Learning.

Get personalized course recommendations, track subjects and courses with reminders, and more.

Someone learning on their laptop while sitting on the floor.