GWAS in Structured Populations by Magnus Nordborg

GWAS in Structured Populations by Magnus Nordborg

International Centre for Theoretical Sciences via YouTube Direct link

Third Bangalore School on Population Genetics and Evolution

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1 of 41

Third Bangalore School on Population Genetics and Evolution

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GWAS in Structured Populations by Magnus Nordborg

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  1. 1 Third Bangalore School on Population Genetics and Evolution
  2. 2 GWAS in structured populations
  3. 3 The agenda
  4. 4 Like begets like Sir Francis Galton et al.
  5. 5 How many genes?
  6. 6 The simplest model possible Fisher 1918
  7. 7 Dominance and epistasis
  8. 8 Average effect
  9. 9 Variance decomposition
  10. 10 Heritability
  11. 11 Typically estimated from parent-offspring regression
  12. 12 How do we map genes?
  13. 13 Linkage mapping
  14. 14 So why do it?
  15. 15 ...if sample size is large enough...
  16. 16 The Human Genome Project meant markers were no longer limiting...
  17. 17 The promise
  18. 18 The HapMap Project
  19. 19 Coronary artery disease
  20. 20 The GWAS debacle
  21. 21 ...height has a heritability of 80%!
  22. 22 A random-effects model is used to estimate variance components
  23. 23 In other words. ..
  24. 24 Could have told you so!
  25. 25 "The world's most expensive test of the mutation-selection balance hypothesis"
  26. 26 There were Cassandras. ..
  27. 27 Population structure confounding in GWAS
  28. 28 GWAS works!
  29. 29 Science
  30. 30 Dealing with "population structure"
  31. 31 We understand this now...
  32. 32 The problem of fine mapping
  33. 33 ..but peak is far from the obvious candidate...
  34. 34 Including two co-factors eliminates spurious peak
  35. 35 A simulation example. ..
  36. 36 Some obvious extensions
  37. 37 Plants are not humans
  38. 38 Adaptation is different from disease
  39. 39 What about skin color?
  40. 40 Cabo Verde
  41. 41 Genome-wide markers explain much more

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