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Glow in the Dark - Using Fluorescence to Observe DNA in a Living Cell
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- 1 Intro
- 2 LECTURE OUTLINE
- 3 DNA IS THE MOLECULE THAT ENCODES THE BLUEPRINT OF LIFE
- 4 AND YET GENOME SIZE DOES NOT PREDICT ORGANISM COMPLEXITY
- 5 AND GENOME SIZE DOES NOT PREDICT GENE COUNT (CODING DNA)
- 6 SO, WHAT FUNCTION DOES ALL OF THE NON-CODING DNA SERVE 7
- 7 DYNAMIC REARRANGEMENT IN LIVE CELL GENOME ARCHITECTURE
- 8 OPTICAL MICROSCOPY ENABLES US TO OBSERVE A LIVING CELL
- 9 BUT DIFFRACTION LIMITS OBSERVATION OF DNA ORGANISATION
- 10 SO, WHAT ASPECTS OF GENOME ARCHITECTURE CAN WE SEE ?
- 11 BREAKTHROUGH COLLABORATION-PHYSICS CHEMISTRY BIOLOGY
- 12 ADVENT OF SUPER-RESOLUTION - SEEING GENOME ARCHITECTURE
- 13 SO, HOW DO WE GET AROUND DIFFRACTION WITH FLUORESCENCE
- 14 WHAT DOES THIS MEAN FOR IMAGING GENOME ARCHITECTURET
- 15 HOW CAN WE IMAGE LIVE CELL NANOSCALE GENOME DYNAMICS
- 16 HISTONE FRET - REPORTS NUCLEAR WIDE NUCLEOSOME PROXIM..
- 17 QUESTION? HOW DOES DNA REPAIR MACHINERY SENSE DNA DAMAGE
- 18 NUCLEAR ARCHITECTURE FACILITATES REPAIR FACTOR NAVIGATIR
- 19 LECTURE SUMMARY
