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Embracing Complexity: Integrating data to build predictive models of complex disease and drug response phenotypes
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Embracing Complexity: Integrating Data for Predictive Disease Models
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- 1 Intro
- 2 Single Molecule Real Time Observation System (Zero Mode Waveguides)
- 3 DNA is but one dimension, and in genetic studies reflects averages in populations: Understanding?
- 4 The problem: Our minds are wired for linear thinking, storytelling, not statistical uncertainty
- 5 Embracing Complexity: Integrating data to build predictive models of complex disease and drug response phenotypes
- 6 Integrating data collected on populations, literature
- 7 Models used to interpret targets under development Novel phosphatase under development at Merck for T2D
- 8 Pharmacologic validation of the network predictions
