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Histones are molecular spools that pack DNA into the cell
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Classroom Contents
DNA, Love, and Gender
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- 1 Intro
- 2 What is "Nature"?
- 3 A metaphor for epigenetics: smart phone
- 4 Basic layout of DNA
- 5 DNA Packing Problem
- 6 Answer: -10 million microscopic spools
- 7 Histones are molecular spools that pack DNA into the cell
- 8 Amazing thing: spools can be programmed in the womb and during life
- 9 Histones contain tails that can be programmed (on/off)
- 10 Epigenetics: complex layer of circuitry that programs the DNA • Each spool is a chemical switch
- 11 DNA sequencing technology has fueled epigenetics
- 12 The killer app: stem cells
- 13 Waddington's epigenetic landscape
- 14 The ski trail metaphor
- 15 Stress response and nature vs. nurture
- 16 Biochemistry of Stress Baseball
- 17 Stress response: cortisol control
- 18 Thermostat controls temperature
- 19 Stress thermostat out of whack!
- 20 Landmark epigenetic study: Mother rats licking and grooming their pups and the effect on pups' DNA
- 21 Environment of mother mouse affects great-grandchildren (Skinner, PLoS One 2012)
- 22 Related epigenetic effects in humans
- 23 Back to smart phone metaphor
- 24 Back to ski trail metaphor
- 25 Epigenetics of Normal Cells
- 26 Other epigenetic programming errors
- 27 Epigenetic cancer drugs
- 28 How do programmers find the right places on the DNA, at the right times?
- 29 RNA is DNA's molecular cousin
- 30 The cutting edge of epigenetics • Linc-RNAs guide programmers to DNA in
