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Chemically Probing the Mechanism of KATP Channels

Chemically Probing the Mechanism of KATP Channels

MolSoft Molecules in Silico via YouTube Direct link

Mechanistic Hypothesis from modeling: Palmitoyl-C166

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Mechanistic Hypothesis from modeling: Palmitoyl-C166

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Chemically Probing the Mechanism of KATP Channels

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  1. 1 Intro
  2. 2 Overview
  3. 3 Sub-classes of Kir channels
  4. 4 Mystery: How does Palm open the channel?
  5. 5 Channel Structure and Mechanism: Gates
  6. 6 Mechanistic Hypothesis from modeling: Palmitoyl-C166
  7. 7 Test of Hypothesis
  8. 8 Phenotypic validation of CL705G
  9. 9 Future Directions

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