Pharmacological Adaptation of Proteostasis to Ameliorate Aging-associated Degenerative Diseases - 2023

Pharmacological Adaptation of Proteostasis to Ameliorate Aging-associated Degenerative Diseases - 2023

Broad Institute via YouTube Direct link

Protein homeostasis network

19 of 42

19 of 42

Protein homeostasis network

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Pharmacological Adaptation of Proteostasis to Ameliorate Aging-associated Degenerative Diseases - 2023

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  1. 1 Introduction
  2. 2 Welcome
  3. 3 Cross beta sheet structures
  4. 4 Transthyroid and amyloidosis
  5. 5 Mutations
  6. 6 Dissociation
  7. 7 Protein Aggregation
  8. 8 Activation barriers
  9. 9 Subunit exchange
  10. 10 clinical trial
  11. 11 liver transplant
  12. 12 lifespan and health span
  13. 13 dementia
  14. 14 CNS phenotype
  15. 15 PET imaging
  16. 16 Brain exposure
  17. 17 Heart failure
  18. 18 Neurodegenerative diseases
  19. 19 Protein homeostasis network
  20. 20 Axon inclusions
  21. 21 A5 in neurons
  22. 22 A5 and Tau
  23. 23 Bloodbrain barrier
  24. 24 Stress response
  25. 25 unfolded protein response
  26. 26 screening strategy
  27. 27 prodrugs
  28. 28 luciferase reporter
  29. 29 model
  30. 30 trafficking index
  31. 31 active
  32. 32 conclusion
  33. 33 antitrypsin
  34. 34 Gaba receptors
  35. 35 Ire XP splice screen
  36. 36 Stress response inhibitors
  37. 37 Technical difficulties
  38. 38 Aggregation in the brain
  39. 39 Interallelic Trend suppressors
  40. 40 PDI inhibitors
  41. 41 Predictive principles
  42. 42 Viral infections

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