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A way forward - smarter biology latent class modeling for subphenotypes
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Classroom Contents
ARDS - The "Real" Definition by Gordon Rubenfeld, MD M.Sc for OPENPediatrics
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- 1 Intro
- 2 Outline
- 3 Everything we know about the ARDS clinical phenotype we learned in 1967
- 4 Syndromes are common in medicine and critical care
- 5 AECC definition Reliability and confusion
- 6 Everyone agrees we need a better ARDS definition but, what does better mean? • Reliability, Validity, Feasibility • How do you study validity without a gold standard?
- 7 Are direct (pulmonary) and indirect (extra-pulmonary) ARDS different?
- 8 Potential impact of recent changes in the definition of ARDS for clinical research
- 9 Berlin Draft Definition
- 10 Novel patient-level meta-analysis of 7 cohorts: 4 Clinical and 3 Physiological
- 11 Evaluation of Severe Ancilary variables identify a smaller group of patients with similar mortality 45% Mortality
- 12 A way forward - smarter biology latent class modeling for subphenotypes
