An Introduction to Drosophila Neuroscience - Lecture 1

An Introduction to Drosophila Neuroscience - Lecture 1

International Centre for Theoretical Sciences via YouTube Direct link

Quantitative high throughput and single fly behaviors

1 of 28

1 of 28

Quantitative high throughput and single fly behaviors

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An Introduction to Drosophila Neuroscience - Lecture 1

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  1. 1 Quantitative high throughput and single fly behaviors
  2. 2 Compact genome
  3. 3 Fast reproduction time
  4. 4 Modular expression systems
  5. 5 Driver line libraries
  6. 6 Effector libraries
  7. 7 Sophisticated developmental tools
  8. 8 Connectomics
  9. 9 An example: From odor encoding to odor learning
  10. 10 Olfaction is a major cue for insects
  11. 11 How do olfactory neurons detect odor molecules?
  12. 12 Each odor is represented by a different pattern of receptor neuron activation
  13. 13 Different smells produce different patterns of brain activation
  14. 14 The mushroom body is required for learned but not innate odor avoidance
  15. 15 The mushroom body maps odor inputs onto motor outputs
  16. 16 Some mushroom body outputs drive attraction and others drive aversion
  17. 17 Each output neuron is modulated by its own dopamine neuron
  18. 18 When dopamine neurons fire after an odor, mushroom body responses to that odor decrease
  19. 19 Neurons that produce innate avoidance are required for attractive memory and vice versa
  20. 20 Another example: Motion vision
  21. 21 Directional motion is computed within the brain
  22. 22 How does this computation happen?
  23. 23 ON and OFF pathways in the visual system
  24. 24 Reconstructing the visual pathway
  25. 25 Electrophysiology from T4/T5 neurons
  26. 26 Inhibition, not multiplication, generates direction selectivity
  27. 27 Matched filters for optic flow
  28. 28 From photoreceptors to feature detectors

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