Completed
Making a third-generation assembly
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Classroom Contents
Evolution of Genomic Oddities
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- 1 Intro
- 2 Evolution of genomic oddities: Making sense of transposons, satellites, and germline/soma genome differences in birds
- 3 Bird genomes: not much going on?
- 4 Three stories about genomic oddities
- 5 Whole genome sequence: (still) impossible
- 6 Genomics: a big and messy puzzle
- 7 How to resolve assembly gaps
- 8 Genomes: microcosms of repeats
- 9 Sex chromosome differentiation
- 10 Making a third-generation assembly
- 11 Low collinearity of W chromosomes...
- 12 with lots of endogenous retroviruses!
- 13 Are W chromosomes toxic like the Y?
- 14 Centromeres are often unassemblable...
- 15 but can be located in assemblies...
- 16 if looking for satellite repeat arrays
- 17 Centromere shifts across songbirds
- 18 Not so stable chromosomes after all?
- 19 Not all cells contain the same genome
- 20 Programmed DNA elimination
- 21 The germline-restricted chromosome...
- 22 Previous work: 18 kb of GRC sequenced
- 23 Tissue-specific linked-read sequencing
- 24 No enrichment in repetitive elements...
- 25 but enrichment in high-copy #genes
- 26 The GRC is expressed in adult gonads...
- 27 Evolutionary strata on the GRC
- 28 Emergence in the passerine ancestor?
- 29 Take-home messages part III
- 30 Future plans: Why does the GRC exist?
- 31 Final thoughts
- 32 Acknowledgments
