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Abnormal Mechanics in Brain Tumors: Implications for Immunotherapy
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- 1 Monthly Seminar on Physical Genomics April 28, 2023
- 2 Outline
- 3 My research experiences
- 4 Abnormal tumor microenvironment fuels treatment resis
- 5 Tumors harbor mechanopathologies including 'solid str
- 6 Solid stress compresses blood vessels in the surroundi
- 7 Solid stress is correlated with neurological dysfunction in
- 8 Mechanical model to apply solid stress in vivo for causal stud
- 9 Chronic compression reduces neurological function
- 10 Methods to measure and map solid stress ex vivo
- 11 Solid stress is a mechanical biomarker of treatment resp
- 12 Strategies to target solid stress
- 13 Losartan enhances therapeutic outcomes in extracranial
- 14 Losartan overcomes solid stress effects in GBM mouse
- 15 Losartan promotes cytotoxic T cell function in GBM
- 16 Losartan repolarizes the myeloid compartment in GE Pro-tumor myeloid cells
- 17 Losartan improves immune checkpoint blockade effi
- 18 Bihemispheric model predicts response to combination
- 19 Immune checkpoint blockade exacerbates GBM ede
- 20 Tumor Immune Microenvironment and Mechanics Lab
