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New ways to study how small molecules stabilise membrane proteins
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A New Phase for Structural Biology - With Carol Robinson
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- 1 Intro
- 2 Count Rumford one of the founding members of the Royal Institution
- 3 J.J. Thomson unveiled the discovery of the electron
- 4 First mass spectrometers
- 5 Mass spectrum of aspirin
- 6 Mass Spectrum of Melanocyte Stimulating Hormone
- 7 Nobel prize for chemistry 2002
- 8 Electrospray - without unfolding
- 9 Folding in the presence of molecular chaperones
- 10 A new phase for structural biology?
- 11 Proteins with many different conformations
- 12 The passage of complexes through the mass spectrometer
- 13 Scientific goals and questions
- 14 Unraveling polydispersity - the alpha crystallins
- 15 Disassembly predicts evolutionary assembly pathways
- 16 Mass spectrometry to identify the building blocks within complexes
- 17 Micelles protect membrane complexes and lipid binding remains intact
- 18 From micelles to membrane proteins in the gas phase
- 19 ATP Synthase - 95:1 DDM: protein
- 20 Mass spectrum of intact ATPase from Thermus thermophilus
- 21 Mass spectral assignment strategy - Massign
- 22 New ways to study how small molecules stabilise membrane proteins
- 23 Monitoring unfolding of AqpZ as a function of POPG binding
- 24 P-glycoprotein - an ABC transporter and drug efflux pump
- 25 Looking for a small difference
- 26 Mechanisms of drug resistance
- 27 Zinc binding to a human metalloprotease ZMPSTE24
- 28 Progeria is a common side effect of anti- HIV drugs
- 29 Processing of lamin A peptides is inhibited by drug binding
- 30 Sugar transporter semiSWEET - remodeling the lipid bilayer
- 31 From Neon to rotary motors to flipping lipids and drugs
