3D Cell Migration Using a Microfluidic Endothelium-on-a-Chip Model

3D Cell Migration Using a Microfluidic Endothelium-on-a-Chip Model

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Intro

1 of 21

1 of 21

Intro

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3D Cell Migration Using a Microfluidic Endothelium-on-a-Chip Model

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  1. 1 Intro
  2. 2 Human Tissue Models for better therapies
  3. 3 Meet the OrganoPlate
  4. 4 OrganoPlate® family
  5. 5 Immune cell migration
  6. 6 Need of novel in vitro immune migration models
  7. 7 Based on publication
  8. 8 Formation of HMEC-1 vessels in the OrganoPlate 3-lane
  9. 9 HMEC-1 vessels can be maintained in immune cell medium
  10. 10 Visualization and quantification of T cells in microfluidic chip
  11. 11 Perfusion of HMEC-1 vessels with fluorescently labelled T cells
  12. 12 ET cells and vasculature interplay
  13. 13 Generation of chemokine gradients in the OrganoPlate 3-lane
  14. 14 T cell extravasation in the presence of chemokine gradients
  15. 15 Donor-to-donor differences are preserved
  16. 16 Induction of vascular inflammation Upregulation of adhesion molecules
  17. 17 Blocking extravasation of T cells
  18. 18 Immune infiltration in the tumor compartment
  19. 19 Immune migration assays are also compatible with HUVECS
  20. 20 The OrganoPlate as a tool to study immune cell extravasation and infiltration
  21. 21 Cell migration in the OrganoPlate

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