Gene Therapy Solutions for Sickle Cell Disease - Lecture 15

Gene Therapy Solutions for Sickle Cell Disease - Lecture 15

The Royal College of Pathologists via YouTube Direct link

Transplant

3 of 26

3 of 26

Transplant

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Gene Therapy Solutions for Sickle Cell Disease - Lecture 15

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  1. 1 Introduction
  2. 2 Outline
  3. 3 Transplant
  4. 4 Gene therapy
  5. 5 Risks
  6. 6 Strategies
  7. 7 Antiviral vectors
  8. 8 CRISPR system
  9. 9 DNA break
  10. 10 HD vs NHEJ
  11. 11 Offtarget genotoxicity
  12. 12 Ontarget genotoxicity
  13. 13 Base transversion
  14. 14 Summary
  15. 15 BB305
  16. 16 Clinical trials
  17. 17 Results
  18. 18 Crisis
  19. 19 Safety
  20. 20 Durability
  21. 21 Conclusion
  22. 22 BC11A
  23. 23 G206
  24. 24 BC118
  25. 25 Excessile
  26. 26 Hemolysis markers

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