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This course focuses on decentralized private computation with a universal setup, aiming to address the limitations of traditional blockchain systems in terms of scalability and privacy. By introducing the VeriZexe instantiation, participants will learn how to execute arbitrary computations off-chain without revealing program logic to the network. The course teaches efficient techniques for transaction generation, memory usage optimization, and the design of gadgets for mathematical operations within the Plonk constraint system. The teaching method involves presenting a new DPC instantiation and benchmarking its performance improvements. This course is intended for individuals interested in blockchain technology, decentralized systems, and privacy-preserving computation.