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Lecture-54 : Polyketide Biosynthesis
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Organic Chemistry in Biology and Drug Development
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- 1 Organic Chemistry in Biology and Drug Development
- 2 Lecture 1 : A brief introduction to Molecules of Life
- 3 Lecture 2 : Biological Macro molecules and Small molecules: Importance and functions
- 4 Lecture 3 : Amino Acids: The building block of proteins
- 5 Lecture 4 : Amino acids: separation and detection, Electrophoresis and Ninhydrin reaction
- 6 Lecture 5 : Method of determination of Amino acid sequence: primary structure of polypeptide/protein
- 7 Lecture 6 : Selective peptide bond cleavage: Enzymatic and Non-enzymatic methods
- 8 Lecture 7 : Peptide synthesis: Protecting groups for amine and carboxyl functionality
- 9 Lecture 8 : Peptide synthesis (continued): Protection, coupling and deprotection methods
- 10 Lecture 9 : Recent development of coupling agents;
- 11 Lecture 10 : Hierarchial structure of proteins: Secondary, tertiary and quaternary structure
- 12 Lecture 11 : Ramachandran plot and protein purification techniques
- 13 Lecture 12 : Protein Purification Techniques (Contd.)
- 14 Lecture 13 : Introduction to Enzymes and its kinetics
- 15 Lecture 14 : Enzyme catalysed reactions and introduction to catalytic activity of proteases
- 16 Lecture 15 : Enzyme Kinetics (Contd.)
- 17 Lecture 16 : Concept of Enzyme Inhibition
- 18 Lecture 17 : Concept of Enzyme Inhibition (Contd.)
- 19 Lecture 18 : Problems on Enzyme Kinetics and Enzyme Inhibition
- 20 Lecture 19 : Synthetic Biology
- 21 Lecture 20 : Synthetic Biology (Contd.)
- 22 Lecture 21 : Synthetic Biology (Contd.)
- 23 Lecture 22 : Nucleic Acid
- 24 Lecture 23 : Nucleic Acid (Contd.)
- 25 Lecture 24 : DNA sequencing method
- 26 Lecture 25 : DNA sequencing method (Contd.)
- 27 Lecture 26 : DNA sequencing method (Contd.)
- 28 Lecture 27 : Synthesis of oligonucleotide
- 29 Lecture 28 : Central dogma: DNA replication, transcription and translation
- 30 Lecture 29 : Central dogma: DNA replication, transcription and translation (Contd.)
- 31 Lecture 30 : Central dogma: DNA replication, transcription and translation (Contd.)
- 32 Lecture 31 : Central dogma: DNA replication, transcription and translation ((Contd.)
- 33 Lecture 32 : Central dogma: DNA replication, transcription and translation (Contd.)
- 34 Lecture 33 : Molecular Biology
- 35 Lecture 34 : Molecular Biology (Contd.)
- 36 Lecture 35 : Chemistry of cofactors/coenzymes
- 37 Lecture 36 : Chemistry of cofactors/coenzymes (Contd.)
- 38 Lecture 37 : Chemistry of cofactors/coenzymes (Contd.)
- 39 Lecture 38 : Chemistry of cofactors/coenzymes (Contd.)
- 40 Lecture 39 : Chemistry of cofactors/coenzymes (Contd.)
- 41 Lecture 40 : Chemistry of cofactors/coenzymes (Contd.)
- 42 Lecture-41: " Introduction to Drug Discovery Process"
- 43 Lecture-42: " Fundamental Principles of Drug Development Process"
- 44 Lecture-43: " Combinatorial chemistry"
- 45 Lecture-44: "Neurotransmitters"
- 46 Lecture-45: " Catechol amine based and GABA neurotransmitters"
- 47 Lecture-46: " Hypertension: humoral mechanism and renin/angiotensin system"
- 48 Lecture-47: " Inhibitor design of angiotensin converting enzyme"
- 49 Lecture 48: Antimicrobial drugs
- 50 Lecture 49: Chemistry of penicillins
- 51 Lecture 50: Resistance to beta-lactam antibiotics
- 52 Lecture 51: Mechanistic studies of beta-lactamase
- 53 Lecture 52: Non beta-lactam antibiotics
- 54 Lecture 53: Mechanistic enzymology of Isopenicillin N synthase
- 55 Lecture-54 : Polyketide Biosynthesis
- 56 Lecture 55 : Biosynthesis of macrolide polyketides and introduction to virus
- 57 Lecture 56 : Anti-viral drugs
- 58 Lecture-57 : Cancer and Chemotherapy
- 59 Lecture-58 : Anti-cancer drugs (contd)
- 60 Lecture 59 : Aromatase inhibition and Anti-ulcer drugs
- 61 Lecture-60 : Cholesterol lowering agents
- 62 Lecture 61 : Cholesterol Biosynthesis
- 63 Lecture-62 : Pharmakinetics and pharmadynamics
- 64 Lecture-63 : QSAR principles
