Leveraging Evolutionary Trade-Offs and Phage Selection Pressure to Reduce Bacterial Pathogenicity

Leveraging Evolutionary Trade-Offs and Phage Selection Pressure to Reduce Bacterial Pathogenicity

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Intro

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1 of 15

Intro

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Leveraging Evolutionary Trade-Offs and Phage Selection Pressure to Reduce Bacterial Pathogenicity

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  1. 1 Intro
  2. 2 Leveraging evolutionary trade-offs and phage selection pressure to reduce bacterial pathogenicity
  3. 3 Phage therapy: a renewed approach
  4. 4 Isolating phage candidates
  5. 5 Incorporating genome sequencing
  6. 6 Measuring phage host-range
  7. 7 Characterizing phage binding
  8. 8 Trade-offs WOULD benefit phage therapy
  9. 9 Identify phages that drive antibiotic resistance trade-offs
  10. 10 Determine likelihood that mutations cause trade-offs
  11. 11 Identify phages that drive virulence trade-offs
  12. 12 Trade-ups WOULD NOT benefit phage therapy
  13. 13 Case 1: Emergency phage therapy in human volunteer
  14. 14 Examining clinical samples pre- vs. post-therapy
  15. 15 Evolutionary prediction

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